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Cbd Oil And The Endocannabinoid System 101

The cannabinoids that come from cannabis also interact with many other receptors in the brain, a good example being CBD. Because of binding to more receptors, cannabinoids induce different effects than endocannabinoids, even if they activate the same cannabinoid receptors. Research has shown that small doses of cannabinoids from cannabis can signal the body to make more endocannabinoids and build more cannabinoid receptors.

Almost Half Of People In The Uk Are Unaware That Medical Cannabis Is Legal

• With respect to the cannabinoids found in cannabis, researchers found that THC binds to both CB1 and CB2 receptors, activating them just like an endocannabinoid would do.
• LPS modulation of cannabinoid receptor expression in myeloid cells depends on the experimental system .
• For example, CB2 receptor mRNA level drops in thioglycollate-elicited macrophages in response to LPS .
• This would avoid the side effects of cannabinoids entering the central nervous system and affecting the brain, in other words feeling high.
• Some researchers are currently looking into whether the endocannabinoid system can be targeted peripherally using synthetic cannabinoids which cannot cross the blood-brain-barrier.

The study of these molecules has been astounding as scientists have proclaimed that they are the most versatile molecules known to exist. This incredible discovery has proven that our endocannabinoid systems regulate a number of functions from pain, immune response, to motor function, sleep, and even memory. The human body has two receptors for cannabinoids the CB1 and CB2 receptors. Although both are found all over the body, CB1 receptors are present in the brain and deal with pain, movement, cognitive function, and mood.

CB2 receptors are more common in the immune system and affect pain and inflammation, among other things. THC attaches to the CB1 receptors, whereas CBD interacts with the CB2 receptors.

Unlike THC which attaches to receptors, CBD does not attach to the CB2 receptor. Rather, researchers believe that CBD influences the body’s use of endocannabinoids .

The main function of the endocannabinoid system is to regulate and maintain bodily homeostasis, while keeping the biological harmony of our body in place in response to environmental changes. When a person consumes cannabis products, these phytocannabinoids mimic the roles of the body’s own endocannabinoids like Anandamide and 2-AG to manipulate the body’s systems. The blood carries the compounds to the brain and other organs throughout the body, introducing them to cannabinoid receptors. Like a key fits into a lock, cannabinoids are designed to link with cannabinoid receptors. When the body synthesizes endocannabinoids or cannabis-derived phytocannabinoids are consumed, the cannabinoids flood the bloodstream in search of ECS receptors in the brain and elsewhere that they can bind with.

Scientists found that both anandamide and 2-AG bind directly to our body’s cannabinoid receptors. Both compounds are in high concentration throughout the brain, especially in reward and pain-related regions. Our bodies are designed with a biological system made up of endocannabinoids called the endocannabinoid system. Endocannabinoids are internal lipid-based neurotransmitters that have the ability to combine themselves with cannabinoid receptors located throughout our body. The endocannabinoid system releases our own cannabinoid molecules that are organically made in our body, and these cannabinoids interact with different receptors to produce different results.

THC and CBD are the most common examples of phytocannabinoids, or cannabinoids that are produced by the hemp plant. These plant-based cannabinoids interact with the same receptors as endocannabinoids, albeit in different ways. For example, THC and anandamide both bind to cannabinoid receptors, potentially inducing a sense of calm and relaxation. However, THC cannot be broken down by the same enzyme CBD cannabinoid as anandamide, so it lingers for much longer, resulting in the distinctive, persistent high that marijuana is known for. The plant-based cannabinoid CBD illustrates this nicely, as it interacts with numerous receptor typesin the brain.

When cannabis or other plant cannabinoid products are consumed, phytocannabinoids are absorbed into the bloodstream where they emulate the behaviors of endocannabinoids and interact with cannabinoid receptors in the body. Cannabinoids are a class of molecules characterized by their ability to activate cannabinoid receptors like CB1 and CB2. Anandamide and 2-AG are the two major endocannabinoids produced naturally in the body. All three of these cannabinoids can activate CB1 and CB2 receptors, although each one has a different potency at each receptor.

The two main endocannabinoids are called anandamide and 2-arachidonoylglycerol (2-AG). In 1994, scientists discovered anandamide, the first endocannabinoid to be identified. Researchers found that anandamide plays an integral, yet still a somewhat mysterious role in the joy and happiness that humans experience.